Description

Morinda Supreme

Morinda Supreme

 

 

Morinda Supreme , also known as noni, has been used for hundreds of years throughout Polynesia for a variety of conditions.

Morinda Citrifolia has been reported to help in immune system modulation, anti-cancer, anti-diabetic, a strong antimicrobial and to enhance cognitive abilities, etc.  it is It is most widely used for it’s antimicrobial and immune modulating properties, and is used by thousands of doctors across the world for this purpose.

It acts as a broad-spectrum antimicrobial, and just not against one certain type of microbe including but not limited to many species of bacteria, fungus, virus, and parasites. One recent study showed it to work against E.coli, Staphylococcus aureus, Candida albicans and Aspergillus niger [1, 2, 3,4]. Morinda also works against Mycoplasma, including: Mycoplasma pneumoniae, Mycoplasma penetrans and Mycoplasma fermentans [5].

Many researchers thought that the antimicrobial properties and anticancer properties of Morinda were due to its immune-stimulatory effects. While this is true, in vivo and in vitro studies have shown it to work as a potent antimicrobial, which not only stimulates the immune system, but also possesses its own antimicrobial properties.

Studies have shown taking Morinda Citrifolia causes an increase in the phagocystosis of pathologic bacteria in addition to activating CD4 and CD8, and increasing immune function [6]. While doing this it also acts as an immune stimulant by activating IL6 cells and stimulating B and T Lymphocytes, demonstrating both its cellular and humoral immune stimulant properties [7, 8, 9]. When treating stomach ulcers the results suggest that Morinda Citrifolia possesses significant antiulcer properties which could be due to the cytoprotective action of the herb and/or strengthening of gastric and duodenal mucosa with the enhancement of mucosal defense [10]. Other studies also show Morinda to be an effective antimicrobial against Helicobacter Pylori, a major factor in peptic ulcers [11].

Similarly, Morinda Supreme has been used to help diabetes and research has now shown that Morinda has multiple active components that act to lower ones blood sugar [14]. In addition to lowering blood sugar levels, it also significantly reduces  wound healing time in diabetics [15].

A novel new use of Morinda could be taking it post surgery since it has an antiemetic property and can help prevent postoperative nausea in patients [16]. It also has been shown to have mild blood pressure lowering properties by causing vasodilation of blood vessels [17].

Morinda Supreme has an anti-jugular vein thrombotic effect and a possible additive antithrombotic effect without the induction of thrombocytopenia [18]. It also protects the brain from stress-induced impairment of cognitive function and that this protective effect may be related to improvement in stress-induced decreases in blood vessel density in the hippocampal dentate gyrus [19]. These mechanisms are two ways that have been proposed for the beneficial affects of giving Morinda to those suffering from ADHD. In addition to ADHD some studies have shown it to help with drug and other addictive characteristics [20].

Morinda Supreme has been shown to increase dopamine and serotonin, which could help alleviate depression. It has been used as a folk remedy for depression for hundreds of years, and this is a potential mechanism behind why it has traditionally helped [21]. In folk medicine Morinda is given in some cultures to help with epileptic seizures, and the above-mentioned increases in serotonin and dopamine could explain its beneficial effects [22].

In clinical practice one unique property of Morinda is that it inhibits the suppression of cell-mediated immunity by immunosuppressive substances. It also inhibits the reduction of IL-2 production and activated Natural Killer Cells [23]. This could be a way to help stimulate the immune system in patients that are on immune-suppressive drugs such as prednisone or cortisone.

Morinda Supreme has potential anticancer and antitumor activity against many forms of cancer including Lewis lung carcinoma, cervical cancer, and others [24, 25, 26]. The mechanism works by multiple pathways including prevention of carcinogen-DNA adduct formation and antioxidant activity [27]. It has also been shown to cause the inhibition of new blood vessel networks to help prevent tumor growth [28]. For those on chemotherapy is has also helped protect the body from the side effects of chemotherapy [29].

Contraindications:

Women who are pregnant or breastfeeding should not take Morinda Supreme as a precautionary measure. Some reports show that those with hyperkalemia should not take Morinda due to its high potassium content, though the amount of potassium per capsule is quite low. This may apply more to drinking noni juice but caution is still advised. Since Morinda has been shown to mildly lower ones blood pressure, one should carefully monitor his or her blood pressure if hypotensive before starting to take Morinda.

Dosage:

For Acute and Chronic conditions people should take 3 pills (or 1 scoop) 3x per day. For Prophylaxis it is recommended that a person take 3 pills (or 1 scoop) per day.

Many physicians use Morinda Supreme not only for treating acute and chronic infections, but recommend it prophylactically when under stressful situations or traveling to areas where mold and other pathogens are common.

We recommend taking it with meals if possible. A very small percentage (<5%) of people taking report minor stomach discomfort if they take it without food on an empty stomach, but report no issues taking it with food.

What Makes Morinda Supreme different from other noni products ?

There are many claims to how effective noni is, but in practice many physicians report not seeing it being very beneficial for their patients.

1) Much of the noni (in juice form) on the market is greatly diluted with other fruit juices to mask the taste, weakening the potency.
2) Most noni on the market has been put through a fermentation process that they feel enhances the product (but clinically we often see the opposite).
3) Most noni is either in pasteurized juice form or a capsule combining the leaves and fruit (We believe the raw powdered fruit without the leaves is the best form).
4) Much of the Hawaiian noni is grown downwind of Kilauea volcano and we believe this could be contaminated with toxic materials that are in the vog (volcanic fog). We believe this could possibly be true for some sources from the Big Island.

These are four of the biggest reasons why many people taking noni get mixed results, but thousands of MDs, DOs, DCs, NDs, LAC, etc. have reported impressive clinical changes with using Morinda Supreme.

*Disclaimer: Supreme Nutrition Products does not claim or intend to represent Morinda Citrifolia as a cancer treatment or cure. Anyone with cancer should see their licensed medical provider; we are just providing research studies regarding using Morinda Citrifolia in cancer treatment

Citations:

1. Usha, R., Sangeetha Sashidharan, and M. Palaniswamy. “Antimicrobial Activity of a Rarely Known Species, Morinda Citrifolia L.” Ethnobotanical Leaflets 3 (2010): n. pag. Web.

2. Selvam, P., N. Murugesh, M. Witvrouw, E. Keyaerts, and J. Neyts. “Studies of Antiviral Activity and Cytotoxicity of Wrightia Tinctoria and Morinda Citrifolia.” Indian Journal of Pharmaceutical Sciences Indian J Pharm Sci 71.6 (2009): 670. Web.

3. Jainkittivong, Aree, Tassanee Butsarakamruha, and Robert P. Langlais. “Antifungal Activity of Morinda Citrifolia Fruit Extract against Candida Albicans.” Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 108.3 (2009): 394-98. Web.

4. Raj, R.K. 1975. Screening of Indigeneous plants for Anthelmintic action against human Ascaris lumbricoides; part II. Indian J. Physiol. Pharmacol. 19: 47-9.

5. Rivera, A., S. Giono, M. Gonzalez, N. Rodriguez, and L. Cedillo. “Antibacterial Effect of Morinda Citrifolia Fruit Juice against Mycoplasmas.” Annals of Biological Research, 2.3 (2011): 491-97. Web.

6. Brooks, V. J., M. Schafer, P. Sharp, J. Xu, J. Cai, N. S. Keuler, R. G. Godbee, S. F. Peek, R. D. Schultz, M. Suresh, and B. J. Darien. “Effects of Morinda Citrifolia (Noni) on CD4+ and CD8+ T-Cell Activation in Neonatal Calves.” Professional Animal Scientist 25.3 (2009): 262-65. Web.

7. Brooks, V. J., M. Schafer, P. Sharp, J. Xu, J. Cai, N. S. Keuler, R. G. Godbee, S. F. Peek, R. D. Schultz, M. Suresh, and B. J. Darien. “Effects of Morinda Citrifolia (Noni) on CD4+ and CD8+ T-Cell Activation in Neonatal Calves.” Professional Animal Scientist 25.3 (2009): 262-65. Web.

8. Nayak, Smita, and Sushma Mengi. “Immunostimulant Activity of the Extracts and Bioactives of the Fruits of Morinda Citrifolia.”Pharmaceutical Biology 47.3 (2009): 248-54. Web.

9. Nayak, Smita, and Sushma Mengi. “Immunostimulant Activity of Noni ( Morinda Citrifolia ) on T and B Lymphocytes.” Pharmaceutical Biology 48.7 (2010): 724-31. Web.

10. Srikanth, J., and P. Muralidharan. “Antiulcer Activity of Morinda Citrifolia Linn Fruit Extract.” Jnl.Sci.Res. Journal of Scientific Research 1.2 (2009): n. pag. Web.

11. Atkinson N. Antibacterial substances from flowering plants. 3. Antibacterial activity of dried Australian Plants by rapid direct plate test. Aust J Exp Biol Med Sci. 1956 Feb;34(1):17–26.

12. Deng, Shixin, ‘Afa K. Palu, Brett J. West, Chen X. Su, Bing-Nan Zhou, and Jarakae C. Jensen. “Lipoxygenase Inhibitory Constituents of the Fruits of Noni ( Morinda Citrifolia ) Collected in Tahiti.” J. Nat. Prod. Journal of Natural Products 70.5 (2007): 859-62. Web.

13. West, Brett J., Shixin Deng, Afa K. Palu, and C. Jarakae Jensen. “Morinda Citrifolia Linn. (Rubiaceae) Leaf Extracts Mitigate UVB-induced Erythema.” Journal of Natural Medicines J Nat Med 63.3 (2009): 351-54. Web.

14. Kamiya, Kohei, Wakako Hamabe, Sachiko Harada, Rie Murakami, Shogo Tokuyama, and Toshiko Satake. “Chemical Constituents of Morinda Citrifolia Roots Exhibit Hypoglycemic Effects in Streptozotocin-Induced Diabetic Mice.” Biological & Pharmaceutical Bulletin Biol. Pharm. Bull. 31.5 (2008): 935-38. Web.

15. Nayak, B.s., G.n. Isitor, A. Maxwell, V. Bhogadi, and D.d. Ramdath. “Wound-healing Activity of Morinda Citrifolia Fruit Juice on Diabetes-induced Rats.” J Wound Care Journal of Wound Care 16.2 (2007): 83-86. Web.

16. Sunisa P, Arunporn I: Morinda Citrifolia Linn. for Prevention of Postoperative Nausea and Vomiting. J Med Assoc Thai 2010, 93(Suppl. 7):S204-S209.

17. Gilani, Anwarul Hassan, Saf-Ur-Rehman Mandukhail, Javeid Iqbal, Masoom Yasinzai, Nauman Aziz, Aslam Khan, and Najeeb-Ur -Rehman. “Antispasmodic and Vasodilator Activities of Morinda Citrifolia Root Extract Are Mediated through Blockade of Voltage Dependent Calcium Channels.” BMC Complement Altern Med BMC Complementary and Alternative Medicine 10.1 (2010): 2. Web.

18. Ayanbule, Funmi, 2Guodong Li, Lin Peng, Jacob Nowicki, Gary Anderson, and 1Mian-Ying Wang. “Anti-jugular Vein Thrombotic Effect of Morinda Citrifolia L. [noni] in Male SD Rats.” Functional Foods in Health and Disease 1.9 (2011): 297-309. Web.

19. Muto J, Hosung L, Uwaya A, Isami F, Ohno M, Mikami T. Morinda citrifolia fruit reduces stress-induced impairment of cognitive function accompanied by vasculature improvement in mice. Physiol Behav. 2010 Sep 1;101(2):211-7.

20. Want MY, Breett JW et al. (2002) Morinda Citrifolia (noni): A literature review and recent advances in noni research. Acta Pharmacol Sin. 23 (12): 1127-1141.

21. Muralidharan, P., V. Ravi Kumar, and G. Balamurugan. “Protective Effect of Morinda Citrifolia Fruits on β-amyloid (25-35) Induced Cognitive Dysfunction in Mice: An Experimental and Biochemical Study.”Phytotherapy Research Phytother. Res. (2009): n. pag. Web.

22. Muralidharan, P., and J. Srikanth. “Anti Epileptic Activity of Morinda Citrifolia Linn Fruit Extract.” E-Journal of Chemistry 7.2 (2010): 612-16. Web.

23. Murata, K., Y. Abe, M. Futamura-Masudaa, A. Uwaya, F. Isami, and H. Matsuda. “Activation of Cell-mediated Immunity by Morinda Citrifolia Fruit Extract and Its Constituents.” Natural Product Communications9.4 (2014): 445-50. Web.

24. Furusawa, E., S. C. Chou, A. Hirazumi, and A. Melera. “Antitumour Potential of Pollen Extract on Lewis Lung Carcinoma Implanted Intraperitoneally in Syngeneic Mice.” Phytotherapy Research Phytother. Res. 9.4 (1995): 255-59. Web.

25. Gupta RK, Banerjee A, Pathak S, et al (2013). Induction of mitochondrial-mediated apoptosis by Morinda citrifolia (noni) in human cervical cancer cells. Asian Pac J Cancer Prev, 14, 237-2.

26. Hirazumi, Anne, and Eiichi Furusawa. “An Immunomodulatory Polysaccharide-rich Substance from the Fruit Juice of Morinda Citrifolia (noni) with Antitumour Activity.” Phytotherapy Research Phytother. Res. 13.5 (1999): 380-87. Web.

27. Wang, M. Y., and C. Su. “Cancer Preventive Effect of Morinda Citrifolia (Noni).” Annals of the New York Academy of Sciences 952.1 (2001): 161-68. Web.

28. Hornick, Conrad A., Amy Myers, Halina Sadowska-Krowicka, Catherine T. Anthony, and Eugene A. Woltering. “Inhibition of Angiogenic Initiation and Disruption of Newly Established Human Vascular Networks by Juice from Morinda Citrifolia (noni).” Angiogenesis 6.2 (2003): 143-49. Web.

29. Akihisa, Toshihiro, Kazumi Matsumoto, Harukuni Tokuda, Ken Yasukawa, Ken-Ichi Seino, Katsuo Nakamoto, Hideki Kuninaga, Takashi Suzuki, and Yumiko Kimura. “Anti-inflammatory and Potential Cancer Chemopreventive Constituents of the Fruits of Morinda Citrifolia (Noni).” J. Nat. Prod. Journal of Natural Products 71.7 (2008): 1322. Web.

More Information:

http://www.noniresearch.org/united_states/english/research/published_2001_to_2005.html

http://www.ctahr.hawaii.edu/noni/chemical_constituents.asp

http://www.chinaphar.com/1671-4083/23/1127.pdf

https://www.mskcc.org/cancer-care/integrative-medicine/herbs/noni

http://www.ncbi.nlm.nih.gov/pubmed/11795436?dopt=Abstract

http://www.fs.fed.us/global/iitf/pdf/shrubs/Morinda%20citrifolia.pdf